Notes
Slide Show
Outline
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The Intolerable Global Burden of Malaria
  • World Malaria Today
  • Georgetown University


  • Joel G. Breman, MD, DTPH
  • Fogarty International Center
  • U.S. National Institutes of Health


  • World Malaria Day, April 25, 2008
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Global Malaria Endemicity Today
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The Intolerable Global Burden of Malaria
  • Human


  • Community


  • Regional/Global


  • Conquest


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The Intolerable Global Burden of Malaria
  • Human


  • Community


  • Regional/Global


  • Conquest


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The Intolerable Global Burden of Malaria
  • Human


  • Community


  • Regional/Global


  • Conquest


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Burden of Malaria in Communities by Age and African Subregion
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The Intolerable Global Burden of Malaria
  • Human


  • Community


  • Regional/Global


  • Conquest


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Plasmodium falciparum in 2005
Clinical Cases
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Population at Risk of P. vivax and
Clinical Cases Per Year (in millions), 2004
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Community Surveys of P. falciparum Prevalence Conducted between 1985 and 2007 in AFRO
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Community Surveys of P. falciparum Prevalence SEARO, WPRO, 1985-2007
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Countries With
Widespread Transmission, 2006
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Community Surveys of P. falciparum Prevalence Conducted between 1985 and 2007 in AMRO
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"U.S"
  •  U.S. civilians
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The Intolerable Global Burden of Malaria
  • Human


  • Community


  • Regional/Global


  • Conquest


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To Halve the Burden of Malaria by 2010
Abuja Malaria Summit, April 2000, revised 2007
  • RBM strategy


  • Prompt access to effective treatment


  • Insecticide-treated nets (ITNs)


  • Prevention and control in pregnant women


  • Epidemics






  • Abuja target (by 2005), RBM (2007)



  • 80% patients using correct/affordable treatment w/in 24 hrs


  • 80% of children <5 years and pregnant women having ITNs


  • 80% of pregnant women using intermittent preventive treatment


  • 60% detected w/in 2 weeks of onset


  • 60% responded to w/in 2 weeks


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Malaria in School Children, Kinshasa, 1981-1983
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Malaria: Prevention and Treatment

    • Artemisinin compounds in combination with lumefantrine, amodiaquine, sulfadoxine–pyrimethamine, or others


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Anopheles Mosquito, Larval Breeding Sites
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Cost-Effectiveness of Interventions Against Malaria in Sub-Saharan Africa
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Increase in Gross Development Product Due to Rapid Scale Up to 30 Countries in Sub-Saharan Africa, 2008-2012
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Malaria Cases and Deaths in Zanzibar and Eritrea, 2000 to 2006
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Research Needs: Disease Burden that Can or Cannot be Averted with Existing Interventions
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Fetal Growth Velocity and Impact of Intermittent Preventive Treatment for Malaria of Mothers
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Overlapping Burden of Neglected Diseases and Malaria
(leprosy, lymphatic filariasis, onchocerciasis, schistosomiasis,
soil-transmitted helminths and trachoma)
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Thank you
  • jbreman@nih.gov
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