16 March 2009
=
New Clad=
e 2.1
and Clade 4 recombinant H5N1 Vaccine Viruses Announced by WHO
=
On March 10 the W=
orld
Health Organization (WHO) posted on their avian flu website under the
“General guidelines” section an important update titled “Availa=
bility
of new recombinant H5N1 vaccine viruses”. These viruses have been developed =
at St.
Jude’s Research Hospital in Memphis, Tennessee (USA) and are available
under a Material Transfer Agreement (MTA).
=
The two new
recombinant viruses are:
Clade 2.1
A/duck/Hunan/795/2002. The HA an=
d NA
sequences are provided on the public website of GenBank and are referenced =
in
the following paper: Wang J. et al. Identification of the progenitors of
Indonesian and Vietnamese avian influenza A (H5N1) viruses from southern Ch=
ina.
J Virol 2008; 82 (7): 3405-3414.
=
Clade 4
A/goose/Guiyang/337/2006. The HA an=
d Na
sequences are provided on the GenBank website and are referenced in the
following paper: Smith GJ. Et al. Emergence and predomi=
nance
of an H5N1 influenza variant in China. Proc Natl Acad Sci 200=
6;
103 (45): 16936-16941.
=
This laboratory at
St. Jude’s is a WHO Collaborating Centre for Studies on the Ecology of
Influenza in Animals.
=
The complete WHO
announcement from March 10 can be found at:
www.who.int/csr/disease/avian_influenza/guidelinestopics/en/ind=
ex.html
Of
note, although the Clade 2.1 virus appears to be derived early on from China
(“duck/Hunan/795/2002” above), today it is recogni=
zed to
be the primary clade of Influenza A (H5N1) that infects humans (and avians)=
in
Indonesia. On the other hand, Clade 4 Influenza A
(H5N1) viruses have not (yet) been reported to infect humans frequently any=
where.
Daniel.R.Lucey, M=
D,
MPH
EROne Institutes,
Department of Emergency Medicine
Washington Hospit=
al
Center
Washington, D.C.<=
o:p>
Website for this
posting (requires Internet Explorer): ww=
w.BePast.org
E-mail:
DRL23@Georgetown.edu
------=_NextPart_01C9A646.E26410A0
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