MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C9BDB9.E89D6B80" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C9BDB9.E89D6B80 Content-Location: file:///C:/9E8BDD12/2009-4-14Newsletter.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" 14 April 2009

14 April 2009

Lack of = fatal H5N1 Avian Flu infections in 31 patients under 10 years of age, compared with 23 deaths in 32 patients > 10 years of age, in Egypt since 2006.

Egypt= has reported a total of 63 patients with laboratory-confirmed H5N1 avian influenza infection (23 fatal, 40 non-fatal cases) to the World Health Organization (WHO) between March 2006 and 8 Apri= l, 2009.  A review by this author= of each of the 63 case reports posted on the WHO avian flu website is summariz= ed below, with a table and figure created to illustrate case fatality rates at different age groups. Of note, there were zero deaths in the 23 patients le= ss than 5 years of age, and zero deaths in the 8 children who were 5-9 years of age.  In contrast, all 23 deat= hs in Egypt w= ere in the 32 remaining patients, ages 10-75 years.

By comparison, us= ing worldwide data, the WHO reported that between 25 November 2003 and 24 Novem= ber 2006 there were 12 deaths in 27 patients less than 5 years of age (44%), an= d 19 deaths in 29 patients (49%) ages 5-9 years with laboratory-confirmed H5N1 infections (WHO Weekly Epidemiologic Record No. 6, 9 Feb 2007 p. 46; table 6).  Reasons for this ap= parent difference in mortality rates in the under 5 years and in the 5-9 year-old groups are uncertain at this point, and likely multifactorial if real (e.g., virologic, epidemiologic, therapeutic, and/or for other reasons).

Also of note, 10 = of the 12 patients with H5N1 virus infection reported to date in 2009 have been less than 5 years of age, while one is 6 years old, and only one is an adult (38 years old). To date, none of these 12 patients have died, although two = have been in critical condition. This age-distribution of non-fatal cases to dat= e in 2009 would be consistent with a continuing pattern in Egypt s= ince 2006 of zero fatalities in persons 0-9 years of age due to H5N1 virus infection.=

A WHO avian flu expert and epidemiologist, John Jabbour, has been actively involved with the Egyptian Ministry of Health and Population (MOHP) since the first patient i= n Egypt w= as diagnosed with the H5N1 virus in March 2006.  In a Reuters News article online 8= April 2009, written by Cynthia Johnston, he was quoted as stating: “There is something strange happening in Egypt. Why in children now and not in adults? We need to see if there are sub-clin= ical cases in the community”.  Such a study is anticipated to begin soon in Egypt. Of note, Jabbour was a= lso quoted stating: “There is no change in the virus at all in the virus strain in Egypt. It is the same since the beginning of the outbreak. There is no mutation, nothing.”

To this author, Jabbour’s comments sound balanced and helpful given current observati= ons. Further studies to address the question of sub-clinical infections, and ong= oing genetic analysis for significant mutations will be important.

See Table 1 and Figure 1 be= low.

 

Daniel R. Lucey, MD, MPH

EROne Institutes, Department of Emergency Medicine

Washington Hospital Center, Washington, D.C

Adjunct Professor of Microbiology and Immunology

Georgetown = University Medical Center

Website = for this posting (use Internet Explorer): www.BePa= st.org

e-mail: DRL23@Georgetown.edu

 

 

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