MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C9B6B7.2761A1B0" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C9B6B7.2761A1B0 Content-Location: file:///C:/9E8BDD12/2009-4-4Newsletter.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" April 4, 2009

April 4, 2009

Levoflox= acin Boxed Warning on Risk of Tendinitis and Tendon Rupture.

In a letter dated March 27, 2009 to Healthcare Professionals who had attended the October 26-= 28, 2008 Infectious Disease national meeting (ICAAC/IDSA) the Vice-President, Medical Affairs for the makers of the antibiotic LEVAQUIN (Levofloxacin) emphasized= the ”Boxed Warning”  t= hat reads as follows:

“Fluoroquin= olones, including LEVAQUIN, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and = in patients with kidney, heart or lung transplants [See Warnings and Precautio= ns]”.

Levofloxacin is a commonly used antibiotic that is approved for multiple clinical indications.  In addition, a r= are indication for which levofloxacin is approved is inhalational anthrax (post-exposure).The antibiotic’s package insert addresses this indica= tion as follows:

“To reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. The effectiveness of LEVAQUIN is based on plasma concentrations achieved in humans, a surrogate endpoint reasonably likely to predict clinical benefit. LEVAQUIN has not been tested in humans for the post-exposure prevention of inhalation anthrax. The safety of LEVAQUIN in adults for durations of thera= py beyond 28 days or in pediatric patients for durations of therapy beyond 14 = days has not been studied. Prolonged LEVAQUIN therapy should only be used when t= he benefit outweighs the risk.”

 =

Daniel R. Lucey, MD, MPH

EROne Institutes, Washington Hospital Center

Department of Microbiology and Immunology

Georgetown University Medical Center, Washington<= /span>, D.C.

Website for this posting (requires Internet Explorer): www.BePast.org

 =

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