MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C9DEA7.06611460" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C9DEA7.06611460 Content-Location: file:///C:/D17BA265/2009-5-27Newsletter.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" 27 May 2009

27 May 2009<= /o:p>

Still no confirmed case in Africa of the novel H1N1 flu virus as WHO reports 13,398 cases in 48 nations, and WHO recommends virus for novel H1N1 vaccines<= /o:p>

As of this morning the World Health Organization (WHO) has posted on a global map showing the = 48 nations with a total of 13,398 cases of lab-confirmed novel H1N1 infections= : http://www.who.i= nt/csr/don/h1n1_20090527_0800.jpg

Strikingly absent= are any confirmed cases from the continent of Africa. Cases have been reported from the Americas, Europe, Oceania, and Asia. Information on this novel virus and preparedness measures such as distribut= ion of the anti-influenza drug “oseltamivir” (“Tamiflu”) and personal protective equipment (“PPE”) across Africa have been noted by WHO officials.  Both WHO regional offices for Africa have updated Information on their websites, including in several languages: =

Eastern Mediterranean Regional Office (EMRO): http://www.emr= o.who.int/csr/h1n1/

WHO Regional Offi= ce for Africa: http://www.afro.who.int/

Given the high le= vel of alertness that nations in Africa have for human cases of avian flu H5N1 (e.g., with documented cases in Egypt, Nigeria, and Djibouti), as well as yearly monitoring for seasonal influenza (e.g., in 2008 South Africa docume= nted oseltamivir-resistant seasonal influenza A (H1N1)), one could anticipate detection of this novel H1N1 virus soon in Africa. As with other parts of t= he world, these initial infections will occur most likely via travelers from H1N1-infected areas.

Thorough surveill= ance testing as well as interventions against this novel H1N1 virus in Africa, f= rom the beginning of the highly predictable outbreaks, will be essential to minimize the morbidity and mortality of this virus in Africa.

In addition, such surveillance and tracking of the new virus in Africa= , once it appears anywhere on the continent, will help the global effort to monitor for changes in the virus that could impact vaccine development and antiviral efficacy. 

International partnerships should be strengthened now in anticipation of these novel H1N1 influenza virus outbreaks occurring in Africa very soon.

On another topic,= on May 26 the WHO posted at the following URL (http://www.who.int/csr/resources/publications/sw= ineflu/vaccine_recommendations/en/index.html) a recommendation on selection of a specific novel H1N1 virus related to an isolate from California be used for potential vaccine development:

“The majority of the novel influenza A (H1N1) isolates are antigenically and genetically related to the A/California/7/2009 (H1N1) v virus. Should vacci= nes be prepared against the

novel influenza A (H1N1) vir= us, it is therefore recommended that vaccines contain the following:=

An A/California/7/2009 (H1N1)v ‐like virus

WHO Collaborating Centres (WHO CCs), Essential Regulatory Laboratories (ERLs) and other partners are developing high‐growth reassortant A/California/7/2009 (H1N1)v ‐like viruses. WHO will announce on its website the availability of these reassortants as soon as they are = available.”

 

 

Daniel R. Lucey, MD, MPH

EROne Institutes, Washington Hospital Center

Adjunct Professor of Microbiology and Immunology

Georgetown University Medical Center

Washington, D.C.=

Website for this posting: www.BePast.org (requires Internet Explorer)

DRL23@Georgetown.edu

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