MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C9CCF3.1227FEA0" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C9CCF3.1227FEA0 Content-Location: file:///C:/9E8BDD12/2009-5-4Newsletter.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" 4 May 2009

4 May 2009

 

Will Sur= vivors of the New Influenza A (H1N1) 2009 Virus be Immune to Re-infection, Protect= ed from Severe Disease if Infected with a Related Flu Virus, and/or Able to Do= nate Immune Plasma?  Lab-Confirmed = Cases reach 1,085 with 26 Deaths, in 21 Nations and 36 US States.

 

 

Looking ahead as = the new Influenza A (H1N1) 2009 virus continues to be confirmed in more persons= in North America, Europe, Asia, South America, the Middle East, and New Zealan= d a crucial set of related questions will surely be asked soon, namely: Will Survivors of the New Influenza A (H1N1) 2009 Virus be Immune to Re-infectio= n, Protected from Severe Disease if Infected with a Related Flu Virus, and/or = Able to Donate Immune Plasma?

 =

These questions, while difficult to answer today, will need to be answered as the coming win= ter influenza months in the Southern Hemisphere approach, and the Fall-Winter months approach in the Northern Hemisphere. Already, some potential analogi= es are being drawn between the current Spring 2009 = new Influenza A (H1N1) virus outbreak (WHO Phase 5 of 6) and the relatively mild new Influenza A (H1N1) virus in the Spring (Northern Hemisphere) of 1918 th= at was followed in the Fall of 1918 by a much more fatal Influenza A (H1N1) pandemic.

 =

These questions h= ave been raised in a number of publications, and in slide presentations at the International Emerging Infectious Disease conference (IMED 2007) and US FDA= , as well in discussions with the WHO, US NIH, in a letter to the Washington Post April 29, 2006, and in a Newsletter in this space May 2, 2006 (1-4).

 =

For example, Barry and colleagues concluded in a paper in the 15 Nov 2008 Journal of Infect= ious Diseases that “Exposure to influenza in the spring and summer of = 1918 provided mortality and morbidity protection during the fall pandemic wave. = The intensity of the first wave may have differed across US cities and countries and may partly explain geographic variation in pandemic mortality rates in = the fall. Pandemic preparedness plans should consider that immune protection co= uld be naturally acquired during the first wave of mild influenza illness.̶= 1;

 =

Depending on the extent of spread of the new Influenza A (H1N1) t= his year and whether it reappears in the Fall, the same hypothesis from 1918 ma= y be tested in the Spring and Fall of 2009.

 =

 =

Daniel R. Lucey, = MD, MPH

EROne Institutes, Department of Emergency Medicine

Washington= Hospital Center

Department of Microbiology and immunology

Georgetown University Medical Cen= ter, Was= hington, D.C.

Website for this posting: www.BePast.org

e-mail: DRL23@Georgetown.edu

 =

References:<= /o:p>

 =

1.       Barry JM, Viboud C, Simonsen L. Cross-Protection between successive waves of the 1918-1919 Influenza Pandemic: epidemiological Evidence from US Army Camps a= nd from Britain. J Infectious Diseases 2008; 198: 1427-34.

2.       Lucey D. Letter to the Editor. The Was= hington Post. April 29, 2006.

3.       Lucey D.  Will Persons who recover from pand= emic flu be immune (protected) from re-infection, and thus able to return to work even without vaccination or antiviral prophylaxis? <= st1:place w:st=3D"on">Washington Newsletter. May 2, 2006. www.BePast.org

4.       Lucey D. I= mmune Survivors in the Management of Pandemic Influenza”. First Internation= al Meeting on Emerging Diseases (IMED 2007) and Surveillance. Vienna, Austria. Feb 24, 2007.

5.        Lucey D. Immune Survivors in the Management of Pandemic Influenza”  US Food and Drug Administra= tion (FDA)/CDER. April 30, 2007. Bldg 29, Bethesda, Maryland. (DVD available---= made for the FDA Commissioner’s Office).

 

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