MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01CA2BB7.33C49050" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01CA2BB7.33C49050 Content-Location: file:///C:/9E8BDD12/2009-9-1Newsletter.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" 1 September 2009

1 September 2009<= o:p>

An Excel= lent Idea: The American Academy of Neurology asks Neurologists to Report any Cases of Guillain-Barre Syndrome after Pandemic = H1N1 Flu Vaccination

In a very positive development the American<= /st1:PlaceName> Academy of Neurology (AAN) announced in a press release August 31 that they will partner with the Centers for Disease Control and Prevention (CDC) to ask neurologists to rep= ort “any possible new cases” of Guillain-Barre syndrome (GBS) that occur after a person receives a pandemic H1N1 influenza vaccine.  This vaccine is anticipated to fir= st be available in mid-October.  Neu= rologists are physicians who specialize in the care of patients with diseases involvi= ng the nervous system. The full story can be found on the website of the American Academy of Neurology at: www.AAN.com

Guillain-Barre syndrome (GBS) is an autoimmune disease in which a person’s immune sy= stem attacks and damages nerves. It can result in weakness, difficulty breathing, numbness or tingling, and is fatal in 4-15% of patients.  GBS “affects between 1 and 4= per 100,000 of the population annually throughout the world…” (Hughes R. et al. NEUROLOGY 2003; 61:736-740).

According to the = AAN press release “It is not anticipated that the 2009 H1N1 vaccine will = have an increased risk of GBS. However, out of an abundance of caution, and given that GBS may be of greater concern with any pandemic vaccine because of the association with the 1976 swine flu vaccine, the CDC and AAN are asking neurologists to report any potential new cases of GBS after-vaccination as = part of the CDC’s national vaccine safety monitoring campaign…All neurologists nationwide who encounter patients with adverse events post-vaccination should use the CDC and FDA Vaccine Adverse Event Reporting System (VAERS) to report their observations” (see www.vaers.hhs.gov and the www.AAN.com websites for standardized onli= ne reporting forms).

This appeal to neurologists across the USA to report even “any potential new cases of GBS” after a person receives the soon-to-be available pandemic H1N1 f= lu vaccine is a very positive development for multiple reasons, includi= ng those below, because it should:

(1)     Maximize t= he chance for early diagnosis of this sometimes very serious disease, so that therapy can be started quickly for that individual, whether or not the GBS = was causally related to the flu vaccine.

(2)     Increase substantially the probability that any true causal link between the pandemic H1N1 flu vaccine and GBS will be recognized as soon as possible, and appropriate responses can be made by persons and organizations involved in = the  US and global pandemic H1N1 flu va= ccine program.

(3)     Demonstrat= e an awareness of, and a positive response to, this potential safety concern that some persons understandably have with respect to the 2009 pandemic H1N1 vaccine, due to the above-mentioned association of GBS with the 1976 swine = flu H1N1 vaccine.

 =

Daniel R. Lucey, MD, MPH

EROne Institutes, Department of Emergency Medicine<= /o:p>

Washingt= on Hospital Center

Adjunct Professor of Microbiology and Immunology

Georgeto= wn University Medical Center, Washington, DC

Website for this posting: www.BePast.org (requires IE)

www.DRL23@Georgetown.edu

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