28 September 2008=
=
WHO upda=
tes
Candidate H5N1 vaccine virus list for potential use as human vaccines<=
/o:p>
=
On Thursday,
September 24, the World Health Organization (WHO) posted on their avian
influenza website (Vaccines and Antivirals section) an update titled “=
;Antigenic
and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viru=
ses
developed for potential use as human vaccines”. The prior summary was from February
2008.
=
This five (5) page
pdf document included the following list of “Reassortants with comple=
ted
regulatory approval”, all of which are available, except for t=
he
Clade 2.1 A/Indoensia/5/2005 that WHO states requires “Indonesian
Government permission”:
=
Clade 1 A/Viet
Nam/1203/2004
Clade 1 A/Viet
Nam/1194/2004
Clade 1 A/Cambodi=
a/R0405050/2007
Clade 2.1 A/ Indonesia/5/2005 (NOTE: “Requires Indonesian =
Government
Permission”)
=
Clade2.2 A/Bar-he=
aded
goose/Qinghai/1A/2005
Clade 2.2 A/whoop=
er
swan/Mongolia/244/2005
Clade 2.2
A/turkey/Turkey/1/2005
=
Clade 2.3.4
A/Anhui/1/2005
Clade 2.3.4 A/=
Japanese
white-eye/Hong Kong/1038/2006
Clade 2.3.4 A/=
duck/Laos/3295/2006
=
=
WHO also provides=
a
list of four H5N1 viruses that are “Reassortants prepared and awaiting
regulatory approval”: These include a clade 2.2 virus from Ind=
ia
(chicken/2006), a clade 2.1 virus from Hunan (duck 2002), a clade
2.3.2 virus from Hong Kong (magpie/2007), and a clade 4 virus from Guiyang (goose/2006).
=
As with the prior=
WHO
summaries on this topic in August 2006, March 2007, and February 2008 this =
is a
valuable document in terms of the ongoing evolution of H5N1 influenza virus=
es
and the respective evolving development of candidate vaccines. <=
/span>
=
As in other
publications, WHO notes that clade 1 viruses initially caused human infecti=
ons
several years ago in Cambodia, China Hong Kong SAR, Thailand and Vietnam;
recently Clade 1 viruses have been found again in poultry in Cambodia,
Thailand, and Viet Nam.
=
Clade 2.1 viruses
continue to cause human and animal infections in Indonesia.
=
Clade 2.2 viruses
have been the most widespread geographically, causing animal infections in =
over
60 nations in Asia, Europe, and Africa.&nb=
sp;
Human infections with Clade 2.2 viruses have been lab-confirmed in
Azerbaijan, Turkey, Egypt, Nigeria, Pakistan, Iraq, Bangladesh, Djibouti, a=
nd
China.
=
Clade 2.3.4 viruses have caused human infections in China, Lao PDR,
Myanmar, and Viet Nam.
=
Clade 4 and Clade=
7
viruses have been reported in some birds in Asia.
=
Currently, the USA
has only one Clade 1 (Viet Nam 2004) based H5N1 vaccine that is FDA-approve=
d.
It requires two shots one month apart, a large amount of antigen (90ug), and
does not contain an adjuvant. It is not commercially available but a limited
supply is in the federal Strategic National Stockpile (SNS). Clade 2 based =
H5N1
virus vaccines are also undergoing testing, however, and additional candida=
te
vaccines are being studied using adjuvants and lower concentrations of H5N1
vaccine antigen.
=
=
Daniel R. Lucey, =
MD,
MPH
EROne Institutes,
Washington Hospital Center
Adjunct Professor,
Microbiology and Immunology
Georgetown Univer=
sity
Medical Center
Washington, D.C.<=
o:p>
Website for this
posting: www.BePast.org
e-mail: DRL23@Georgeton.edu
------=_NextPart_01C9225E.5C86AD10
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